Ville Haute
Staying in Ville Haute puts the museum, the Corniche and the Place d'Armes cafes on your doorstep, so you can walk to Casino Luxembourg - Forum d'art contemporain and the palace, cathedral and Hôtel de Ville within minutes. Among the listed hotels here, Hotel Le Place d’Armes Relais & Châteaux is 220 m away, Grand Hotel Cravat 190 m, Hotel Simoncini 200 m and Hotel Francais 230 m, all within a 3-minute walk. After the museum, the district turns museum-like calm once the day crowds leave.
Pfaffenthal
Pfaffenthal lies in the Alzette gorge below the upper city, so a stay here means climbing up to Ville Haute to reach Casino Luxembourg - Forum d'art contemporain and the Chemin de la Corniche. None of the hotels in this list sit in Pfaffenthal, but the gorge setting gives you the valley quiet and the same sandstone cliffs from below, and the walk up brings you out near the Bock Casemates and the museum without needing transport.
Gare
The Gare area around the station is the main transport hub, useful if you arrive by train or want easy connections before walking or riding up to Casino Luxembourg - Forum d'art contemporain in Ville Haute. No hotel in this list is in Gare, but staying there keeps you close to rail links and the city's bus and tram network; the free tram to the upper city still adds time each way, so plan the climb up to the museum and the Corniche as part of your day.